FHL1 adds some muscle
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چکیده
منابع مشابه
FHL1 adds some muscle
can bind to either ankyrin in vitro, what makes the channels preferentially bind to ankyrin G in vivo? To answer this question, Bréchet et al. homed in on the precise residues in sodium channels that are required for the interaction with ankyrin G. They pinpointed a sequence of residues that looked like a target for phosphorylation by CK2, and sure enough, it was. CK2 phosphorylated the sodium ...
متن کاملFHL1 activates myostatin signalling in skeletal muscle and promotes atrophy
Myostatin is a TGFβ family ligand that reduces muscle mass. In cancer cells, TGFβ signalling is increased by the protein FHL1. Consequently, FHL1 may promote signalling by myostatin. We therefore tested the ability of FHL1 to regulate myostatin function. FHL1 increased the myostatin activity on a SMAD reporter and increased myostatin dependent myotube wasting. In mice, independent expression of...
متن کاملA zebrafish model for FHL1-opathy reveals loss-of-function effects of human FHL1 mutations
Missense mutations in the four and a half LIM domain 1 (FHL1) gene were found to cause X-linked inherited myopathies of both skeletal and heart muscle. However, the mechanisms by which FHL1 mutations impact on FHL1 function and lead to alteration of muscle structure and function have not been deciphered yet. We generated here by Morpholino-modified antisense oligonucleotide-mediated gene knockd...
متن کاملIsolation and characterization of a new FHL1 variant (FHL1C) from porcine skeletal muscle.
Four and a half LIM domain protein 1 (FHL1) was initially described as an abundant skeletal muscle protein with four LIM domains and a GATA like zinc finger. FHL1 was shown to be expressed in skeletal muscle as well as in a variety of other tissues. Recently, alternatively spliced FHL1 mRNAs were identified coding for C-terminal truncated proteins. The tissue distribution of these variants is m...
متن کاملSkeletal muscle LIM protein 1 (SLIM1/FHL1) induces 5 1-integrin-dependent myocyte elongation
McGrath, Meagan J., Christina A. Mitchell, Imogen D. Coghill, Paul A. Robinson, and Susan Brown. Skeletal muscle LIM protein 1 (SLIM1/FHL1) induces 5 1-integrin-dependent myocyte elongation. Am J Physiol Cell Physiol 285: C1513–C1526, 2003. First published August 13, 2003; 10.1152/ajpcell.00207.2003.—Skeletal muscle LIM protein 1 (SLIM1/FHL1) contains four and a half LIM domains and is highly e...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2008
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1836iti5